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KMID : 0380620140460030375
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Korean Journal of Food Science and Technology
2014 Volume.46 No. 3 p.375 ~ p.383
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Blood Pressure Modulating Effects of Black Raspberry Extracts in vitro and in vivo
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Lee Jung-Hyun
Choi Hye-Ran
Lee Su-Jung
Lee Min-Jung
Ko Young-Jong
Kwon Ji-Wung
Lee Hee-Kwon
Jeong Jong-Tae
Lee Tae-Bum
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Abstract
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This study aimed to investigate the effects of 50% ethanol extract of ripe black raspberry (Rubus occidentalis, RBR) on hypertension in human umbilical vein endothelial cells (HUVECs) and in spontaneously hypertensive rats (SHR). Angiotensin converting enzyme (ACE) inhibition and activation of nitric oxide production by endothelial nitric oxide synthase were significantly regulated by RBR in HUVEC cells. Moreover, the SHR showed significantly higher levels of blood pressure, ACE, renin, endothelin-1, and interleukin-6 than Wistar Kyoto rats (WKY). However, treatment with captopril and RBR decreased the levels of these hypertension-related events in the SHR. The renal arteriole showed greater media thickness/lumen diameter (%) in the SHR than in the WKY. However, media thickness/lumen diameter (%) was reduced in SHR by treatment with captopril and RBR. In addition, the number of eosinophilic cardiac muscle cells was decreased in the heart muscles after treatment with captopril and RBR. Therefore, this study suggests that 50% ethanol extract of RBR may be useful for the prevention and treatment of high blood pressure.
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KEYWORD
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black raspberry, blood pressure, renin-angiotensin system, human umbilical vein endothelial cell line, spontaneously hypertensive rat
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